Microbial Reduction of Ketopantoyl Lactone to Pantoyl Lactone1
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چکیده
منابع مشابه
Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.
Spectral and chromatographic data as well as methods for synthesis of 14C-labeled ketopantoic acid, ketopantoyl lactone, pantoic acid, and pantoyl lactone are presented. The products of ketopantoic acid and ketopantoyl lactone reductases were characterized as pantoic acid and pantoyl lactone, respectively. Unlike pantoyl lactone, ketopantoyl lactone spontaneously hydrolyzes and has a half-life ...
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In this study, the ability of two antibiotics daptomycin and pantoyl lactone to inhibit growth of horse originated pathogen Streptococcus equi by disrupting plasma membrane of the bacterium was investigated using agar diffusion and micro tube dilution methods. The results obtained from this study indicated that daptomycin was more effective in inhibiting the growth of the pathogen in vitro than...
متن کاملKetopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
The stereospecificity of hydrogen transfer from NADPH to the appropriate carbonyl substrate catalyzed by ketopantoic acid and ketopantoyl acid and ketopantoyl lactone reductases of yeast (Saccharomyces cerevisiae) and Escherichia coli has been determined. Yeast and E. coli ketopantoic acid reductases are B-specific enzymes which transfer hydrogen from [4B-3H]-NADPH to ketopantoic acid to form [...
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Microbial b-lactone natural products An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology. Obafluorin is an antimicrobial b-lactone compound produced by the bacterium Pseudomonas fluorescens. In this study, the compound was synthesized, analysed chemically and tested for biological activity. The triedimycins are a class of spiro b-lactones. They are n...
متن کاملLplR, a repressor belonging to the TetR family, regulates expression of the L-pantoyl lactone dehydrogenase gene in Rhodococcus erythropolis.
The L-pantoyl lactone (L-PL) dehydrogenase (LPLDH) gene (lpldh) has been cloned from Rhodococcus erythropolis AKU2103, and addition of 1,2-propanediol (1,2-PD) was shown to be required for lpldh expression in this strain. In this study, based on an exploration of the nucleotide sequence around lpldh, a TetR-like regulator gene, which we designated lplR, was found upstream of lpldh, and three pu...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1974
ISSN: 0003-6919
DOI: 10.1128/aem.27.1.130-134.1974